SPF-Rx

SPF-Rx

SPF Rx: Strategic Prevention Framework for Prescription Drugs

The SPF Rx program in Nashville, Tennessee, is funded by the Substance Abuse and Mental Health Services Administration (SAMSHA) as part of a national effort to address prescription drug misuse—particularly opioids.

Launched by SAMHSA in 2016, the SPF Rx initiative supports states, tribes, and communities in preventing prescription drug misuse through the Strategic Prevention Framework (SPF).

National Focus Areas Include:

• Reducing opioid overdoses
• Enhancing Prescription Drug Monitoring Programs (PDMPs)
• Educating providers and the public on safe prescribing practices

Why Nashville?

Tennessee has consistently ranked among the states with the highest opioid prescription rates in the U.S. In Davidson County (Nashville), rising opioid-related deaths—including those involving heroin and fentanyl—prompted urgent action and federal support through SPF Rx.

Nashville’s Key Goals

• Strengthen PDMP Use

  Improve real-time tracking of controlled substance prescriptions.
• Provider Education

  Train healthcare professionals in responsible opioid prescribing practices.
• Community Prevention

  Raise public awareness about safe storage and proper disposal of medications.
• Data-Driven Strategies

  Use local overdose data to identify and respond to high-risk areas.

Expected Outcomes & Impact

Through SPF Rx, Nashville aims to:

• Reduce inappropriate opioid prescribing
• Expand community access to naloxone
• Complement broader state-level prevention and wellness initiatives